THE BEST SIDE OF FENTANYL CLEARANCE

bosentan will lower the level or effect of fentanyl by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Coadministration of fentanyl with CYP3A4 inducers could lead into a decrease in fentanyl plasma concentrations, lack of efficacy or, potentially, development of a withdrawal syndrome in a affected person that